COX-2 Gene Polymorphism and Lung Cancer Risk
Author Information
Author(s): Park Jung Min, Choi Jin Eun, Chae Myung Hwa, Lee Won Kee, Cha Sung Ick, Son Ji-Woong, Kim Chang Ho, Kam Sin, Kang Young Mo, Jung Tae Hoon, Park Jae Yong
Primary Institution: Kyungpook National University
Hypothesis
The COX-2 8473T>C polymorphism may influence susceptibility to lung cancer.
Conclusion
The COX-2 8473T>C polymorphism is associated with a decreased risk of adenocarcinoma of the lung.
Supporting Evidence
- The COX-2 8473T>C polymorphism was associated with a significantly decreased risk of adenocarcinoma.
- The protective effect was significant in males, older individuals, and ever-smokers.
- No significant association was found for squamous cell carcinoma or small cell carcinoma.
Takeaway
Some people have a gene change that makes them less likely to get a type of lung cancer called adenocarcinoma.
Methodology
A case-control study comparing 582 lung cancer patients with 582 healthy controls, using PCR-based genotyping.
Limitations
Findings may be due to chance because of multiple comparisons and small subgroup sizes.
Participant Demographics
Participants were ethnic Koreans, with 582 lung cancer patients and 582 healthy controls matched for age and gender.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI = 0.46–0.90
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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