Does carbon monoxide treatment alter cytokine levels after endotoxin infusion in pigs? A randomized controlled study
2008
Effects of Carbon Monoxide on Inflammation in Pigs
Sample size: 20
publication
Evidence: moderate
Author Information
Author(s): Åberg Anna-Maja, Abrahamsson Pernilla, Johansson Göran, Haney Michael, Winsö Ola, Larsson Jan Erik
Primary Institution: Umeå University Hospital
Hypothesis
A low dose of CO has protective anti-inflammatory effects during sepsis.
Conclusion
5% COHb does not modify the cytokine response following endotoxin infusion in pigs.
Supporting Evidence
- Cytokine levels increased in response to endotoxin infusion.
- No significant differences in cytokine levels were found between CO-treated and control groups.
- The study used a porcine model to mimic human sepsis.
Takeaway
The study tested if carbon monoxide could help reduce inflammation in pigs, but it didn't work.
Methodology
20 female pigs were infused with endotoxin and treated with inhaled CO or served as controls.
Potential Biases
The study was open-label, which may introduce bias in treatment administration.
Limitations
Three animals died during the study, which may have affected the results.
Participant Demographics
20 female pigs weighing 23–40 kg.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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