Estrogenic Effects of Peas and the Role of (+)-Pisatin
Author Information
Author(s): Belgodere Jorge A., Benz Megan C., Kpeli G. Wills, Elliott Jack R., Elliott Steven, North Jack D., Ponder Isaac J., Ma Peng, Dietrich Sophie R., Cheng Thomas, Nguyen Khoa, Tilghman Syreeta L., McLachlan John A., Zou Binghao, Anbalagan Muralidharan, Rowan Brian, Mondrinos Mark, Wiese Thomas E., Hoang Van T., Collins-Burow Bridgette M., Martin Elizabeth C., Burow Matthew E., Boué Stephen M.
Primary Institution: Tulane University Health Science Center
Hypothesis
The study investigates the estrogenic activity of phytoalexins produced in snow and green peas when elicited with Aspergillus sojae.
Conclusion
(+)-Pisatin from elicited snow peas shows significant estrogenic activity and can enhance breast cancer cell proliferation.
Supporting Evidence
- Elicited extracts increased estrogenic activity in breast cancer cells.
- (+)-Pisatin was identified as the primary phytoalexin produced in snow peas.
- RNA sequencing suggested functional effects on endothelial cells.
- Context-dependent effects of (+)-pisatin should be considered in therapeutic investigations.
Takeaway
This study found that a compound from peas can act like estrogen and help breast cancer cells grow, but it can also block estrogen's effects in some cases.
Methodology
The study involved eliciting green and snow pea extracts with Aspergillus sojae and analyzing their estrogenic activity using breast cancer cell lines.
Limitations
The study primarily focuses on in vitro results, which may not fully represent in vivo effects.
Statistical Information
P-Value
p < 0.0001
Statistical Significance
p < 0.0001
Digital Object Identifier (DOI)
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