Neuropsychological Outcomes in Children with Optic Pathway Tumors Treated with Chemotherapy
Author Information
Author(s): Lacaze E, Kieffer V, Streri A, Lorenzi C, Gentaz E, Habrand J-L, Dellatolas G, Kalifa C, Grill J
Primary Institution: Gustave Roussy Institute
Hypothesis
What are the neuropsychological deficits in children with optic pathway glioma treated with chemotherapy as first-line treatment?
Conclusion
Children with optic pathway gliomas treated with chemotherapy show preserved neuropsychological outcomes compared to those treated with irradiation.
Supporting Evidence
- Children treated with chemotherapy only had a higher mean full-scale IQ compared to those who received radiotherapy.
- Children with neurofibromatosis type 1 showed more significant neuropsychological deficits.
- Statistically significant differences were found in verbal IQ and performance IQ among different treatment groups.
Takeaway
This study looked at kids with brain tumors and found that those who got chemotherapy first did better in school than those who had radiation treatment.
Methodology
The study assessed neuropsychological outcomes in children treated with BBSFOP chemotherapy, using various standardized tests for intellectual ability.
Potential Biases
Potential bias due to the non-randomized nature of treatment assignment and the varying severity of conditions among participants.
Limitations
The study's results may not fully account for the severity of the disease in children who required radiotherapy.
Participant Demographics
27 children (11 boys and 16 girls) aged 5 months to 15.7 years, with some having neurofibromatosis type 1.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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