Effects of Fermented Radix Astragali on Hyperuricemia
Author Information
Author(s): Chen Caiyun, Liu Keyu, Wang Yishu, Song Xinru, Gao Wenjing, Wang Yanlin, Chen Yuxin, An Ziqi, Yin Changting, Wang Haiyan, Wang Shaoping
Primary Institution: Binzhou Medical University, Yantai, China
Hypothesis
This research aimed to probe the effects of fecal microbiota and Lactobacillus acidophilus on the metabolism of Radix Astragali and Poria cocos solid fermenting Radix Astragali.
Conclusion
The study revealed that fermented Radix Astragali effectively reduced uric acid levels and showed protective effects on the liver and kidney in hyperuricemia mouse models.
Supporting Evidence
- FRA effectively reduced blood levels of uric acid, triglycerides, and liver enzymes in hyperuricemia mice.
- Network pharmacology identified 93 common targets for RA, Poria cocos, and hyperuricemia.
- Molecular docking analysis showed strong binding of active compounds to core targets.
Takeaway
This study shows that a special type of fermented herb can help lower bad stuff in the blood that can make you sick.
Methodology
The study used in vitro fermentation with fecal microbiota and Lactobacillus acidophilus, followed by pharmacodynamic experiments in a hyperuricemia mouse model.
Participant Demographics
Four healthy donors (two males and two females) provided fecal samples for the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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