High p53 Levels in Colorectal Cancer and Prognosis
Author Information
Author(s): Adrover E, Maestro M L, Sanz-Casla M T, Barco V del, Cerdán J, Fernández C, Balibrea J L
Primary Institution: Department of Oncology, Hospital ‘Virgen de la Luz’, Cuenca, Spain; Departments of Tumour Biology, Surgery, and Epidemiology, Hospital Clínico ‘San Carlos’, Madrid, Spain
Hypothesis
Does high p53 expression correlate with better prognosis in colorectal cancer patients?
Conclusion
High levels of p53 expression in colorectal cancer are associated with prolonged disease-free survival, especially in stage III patients.
Supporting Evidence
- 42% of colorectal cancer samples showed detectable p53 levels.
- 25% of tumors had high p53 levels based on the cut-off value.
- No association was found between p53 expression and various patient demographics or tumor characteristics.
- High p53 levels correlated with prolonged disease-free survival at a median follow-up of 60 months.
- The survival advantage was most significant in stage III cancer patients.
Takeaway
If a colorectal cancer patient has high p53 levels, they might have a better chance of staying cancer-free for a longer time.
Methodology
A quantitative luminometric immunoassay was used to measure p53 protein levels in colorectal cancer samples.
Statistical Information
P-Value
0.05
Statistical Significance
p=0.05
Digital Object Identifier (DOI)
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