Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis
2003
Hydrogen Ion Dynamics and Cancer Blood Vessel Formation
publication
Evidence: moderate
Author Information
Author(s): Orive G, Reshkin S J, Harguindey S, Pedraz J L
Primary Institution: University of the Basque Country
Hypothesis
The study investigates the role of hydrogen ion transport and intracellular pH in cancer angiogenesis and antiangiogenesis.
Conclusion
The review highlights the significant relationship between hydrogen ion dynamics and the processes of tumor angiogenesis and antiangiogenesis.
Supporting Evidence
- Elevations in intracellular pH are linked to tumor growth and drug resistance.
- Cytosolic hyperacidification is associated with programmed cell death.
- Angiogenesis is crucial for tumor growth and metastasis.
Takeaway
This study looks at how the movement of hydrogen ions in cancer cells affects the growth of blood vessels that feed tumors.
Methodology
The review synthesizes recent research findings on hydrogen ion dynamics and their implications for cancer angiogenesis.
Digital Object Identifier (DOI)
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