Dynamic Regulation of Gene Expression by Transcription Factors
Author Information
Author(s): He Feng, Jan Buer, An-Ping Zeng, Rudi Balling
Primary Institution: HZI- Helmholtz Centre for Infection Research
Hypothesis
How do combinations of transcription factors quantitatively control gene expression?
Conclusion
Dynamic cumulative regulation is a key principle in how transcription factors control gene expression.
Supporting Evidence
- 67.1% of three-regulator motifs showed significant correlation with target gene expression.
- 32.9% of two-regulator motifs showed significant correlation with target gene expression.
- The results were verified with a second independent set of time-series data.
Takeaway
This study shows that when different proteins work together to control genes, the timing of their actions is really important for how well they work.
Methodology
The study used high-resolution time-series data and analyzed the combinatorial expression profiles of transcription factors in yeast.
Limitations
The study may not account for all possible interactions and conditions affecting gene regulation.
Participant Demographics
Yeast transcription factors and their target genes.
Statistical Information
P-Value
2.7E-3
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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