Low Cyclin D1 Linked to Local Recurrence in Breast DCIS
Author Information
Author(s): Jirström K, Ringberg A, Fernö M, Anagnostaki L, Landberg G
Primary Institution: Lund University, Malmö University Hospital
Hypothesis
The study aims to determine the expression of various cell cycle regulating proteins in ductal carcinoma in situ (DCIS) and their associations with local recurrence.
Conclusion
High cyclin D1 expression in DCIS lesions is associated with a longer time to local recurrence.
Supporting Evidence
- High cyclin D1 expression was linked to a longer time to recurrence.
- Only one local recurrence was seen in the group that received adjuvant radiotherapy.
- Patients with low cyclin D1 and diffuse growth pattern had the highest local recurrence rate.
Takeaway
This study found that lower levels of a protein called cyclin D1 in certain breast tumors can lead to more chances of the cancer coming back.
Methodology
The study used tissue microarrays to analyze the expression of cell cycle regulatory proteins in 177 patients with DCIS.
Potential Biases
There may be selection bias due to the specific criteria for including patients in the study.
Limitations
The study had a relatively small number of local recurrence events, which may limit the statistical power.
Participant Demographics
Patients were treated for DCIS at a single institution in Sweden between 1987 and 1991.
Statistical Information
P-Value
0.02
Confidence Interval
0.036 to 0.589
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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