Gene Interaction and Breast Cancer Risk
Author Information
Author(s): Cox David G, Tamimi Rulla M, Hunter David J
Primary Institution: Harvard School of Public Health
Hypothesis
Do the MnSOD and GPX-1 gene polymorphisms together influence breast cancer risk?
Conclusion
Polymorphisms in the GPX-1 and MnSOD genes are associated with an increased risk of breast cancer.
Supporting Evidence
- Neither MnSOD nor GPX-1 polymorphisms alone increase breast cancer risk.
- Carrying both the Ala16Ala genotype of MnSOD and the Leu198Leu genotype of GPX-1 increases breast cancer risk.
Takeaway
Some genes can work together to increase the risk of getting breast cancer, even if they don't do it alone.
Methodology
A nested case-control study comparing 1262 women with breast cancer to 1533 disease-free women, genotyping specific polymorphisms.
Potential Biases
Potential biases related to matching controls and self-reported data.
Limitations
The study may require larger sample sizes to detect interactions with lower prevalence polymorphisms.
Participant Demographics
Women from the Nurses' Health Study, matched by age and other factors.
Statistical Information
P-Value
0.03
Confidence Interval
1.09 – 3.19
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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