Effect of a tumour-derived lipid-mobilising factor on glucose and lipid metabolism in vivo
2002
Effect of Tumor-Derived Lipid-Mobilizing Factor on Metabolism
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): Russell S T, Tisdale M J
Primary Institution: Pharmaceutical Sciences Research Institute, Aston University
Hypothesis
What is the effect of lipid mobilizing factor on glucose and lipid metabolism in vivo?
Conclusion
The study found that lipid mobilizing factor significantly increases glucose oxidation and lipid metabolism in mice.
Supporting Evidence
- Lipid mobilizing factor increased glucose oxidation to CO2 in treated mice.
- Overall lipid oxidation was 67% greater in mice treated with lipid mobilizing factor compared to controls.
- Glucose utilization was significantly elevated in brain, heart, brown adipose tissue, and gastrocnemius muscle.
Takeaway
This study shows that a substance from tumors can help the body use fat and sugar better, which might help people with cancer who are losing weight.
Methodology
Ex-breeder male NMRI mice were treated with lipid mobilizing factor and various metabolic measurements were taken.
Participant Demographics
Ex-breeder male NMRI mice, 35-40g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website