Amerindian Helicobacter pylori Strains Go Extinct, as European Strains Expand Their Host Range
Author Information
Author(s): Domínguez-Bello Maria G., Pérez Maria E., Bortolini Maria C., Salzano Francisco M., Pericchi Luis R., Zambrano-Guzmán Orlisbeth, Linz Bodo
Hypothesis
The Amerindian H. pylori strains would be the least diverse due to their coevolution with a less genetically diverse human population.
Conclusion
The study found that Amerindian H. pylori strains are less genetically diverse and may be disappearing as European strains expand their host range.
Supporting Evidence
- Amerindian H. pylori strains showed the least genetic diversity.
- European H. pylori strains exhibited significant multilocus sequence mosaicism.
- Strain diversity in Amerindians increased when grouped by host.
Takeaway
This study shows that the bacteria living in our stomachs can change based on the people they live with, and some types of these bacteria are disappearing.
Methodology
Analyzed multilocus sequences of 7 housekeeping genes from 131 H. pylori strains cultured from various human populations.
Potential Biases
Potential bias in strain selection and geographic representation.
Limitations
The study primarily focused on specific populations and may not represent all human groups.
Participant Demographics
Strains from Africans, Spanish, Koreans, Amerindians, and South American Mestizos.
Statistical Information
P-Value
p<2.2×10−16
Statistical Significance
p<2.2×10−16
Digital Object Identifier (DOI)
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