Glycyrrhizin Reduces Eye Pressure in Rabbits
Author Information
Author(s): Song Zhengyu, Gong Yuanyuan, Liu Haiyun, Ren Qiushi, Sun Xiaodong
Primary Institution: Shanghai First People’s Hospital, School of Medicine, Shanghai JiaoTong University
Hypothesis
Can glycyrrhizin reduce ocular hypertension induced by triamcinolone acetonide in rabbits?
Conclusion
Glycyrrhizin can lower eye pressure caused by triamcinolone in rabbits and improve their eye function.
Supporting Evidence
- IOP was significantly elevated in the TA group compared to controls.
- Glycyrrhizin treatment significantly reduced IOP in the TA+GL and GL+TA groups.
- Electrophysiological parameters improved after glycyrrhizin treatment.
Takeaway
This study found that a substance called glycyrrhizin can help lower eye pressure in rabbits that had high pressure from a medicine called triamcinolone.
Methodology
Forty rabbits were divided into five groups and treated with different combinations of glycyrrhizin and triamcinolone, with measurements taken over 28 days.
Limitations
The study had a limited number of rabbits and dosage range, and the molecular mechanisms remain unclear.
Participant Demographics
New Zealand White Rabbits, male, weighing 2.0 to 2.2 kg.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website