Hydroxylated Metabolites of Polybrominated Diphenyl Ethers in Human Blood Samples
Author Information
Author(s): Qiu Xinghua, Bigsby Robert M., Hites Ronald A.
Primary Institution: Indiana University
Hypothesis
What are the concentrations of hydroxylated PBDEs in blood from pregnant women and their newborns?
Conclusion
Hydroxylated metabolites of PBDEs are accumulating in human blood, with different metabolic patterns observed compared to mice.
Supporting Evidence
- 5-HO-BDE-47 and 6-HO-BDE-47 were the most abundant metabolites found in human blood.
- The ratio of hydroxylated metabolites to their PBDE precursors ranged from 0.10 to 2.8.
- Hydroxylated metabolites of PBDEs may accumulate in human blood.
Takeaway
This study found that certain chemicals used in flame retardants are building up in the blood of pregnant women and their babies.
Methodology
Twenty human blood samples were analyzed for PBDEs and HO-PBDEs using gas chromatography mass spectrometry.
Limitations
The study had a small sample size and only one set of paired maternal-fetal samples.
Participant Demographics
Blood samples were collected from pregnant women and their newborns in Indianapolis, Indiana.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website