Angiogenesis-Related Gene Expression Profile in Advanced Ovarian Carcinoma
Author Information
Author(s): Mendiola Marta, Barriuso Jorge, Redondo Andrés, Mariño-Enríquez Adrián, Madero Rosario, Espinosa Enrique, Vara Juan Ángel Fresno, Sánchez-Navarro Iker, Hernández-Cortes Ginés, Zamora Pilar, Pérez-Fernández Elia, Miguel-Martín María, Suárez Asunción, Palacios José, González-Barón Manuel, Hardisson David
Primary Institution: Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain
Hypothesis
This study aimed to identify an angiogenesis-related gene expression profile with prognostic value in advanced ovarian carcinoma patients.
Conclusion
A prognostic model for advanced ovarian carcinoma can be generated based on angiogenesis-related genes using formalin-fixed paraffin-embedded samples.
Supporting Evidence
- A 34-gene profile was identified that predicts overall survival in ovarian carcinoma patients.
- The high-risk group had a median overall survival of 28.3 months.
- The profile maintained independent prognostic value in multivariate analysis.
- Median progression-free survival for the high-risk group was 15.0 months.
- The profile distinguished two groups of patients with different outcomes.
Takeaway
Researchers found a way to predict how long patients with advanced ovarian cancer might live by looking at certain genes related to blood vessel growth.
Methodology
The study analyzed RNA from tumor samples of 61 patients using quantitative real-time PCR to measure the expression of 82 angiogenesis-related genes.
Limitations
The study analyzed a relatively small number of samples.
Participant Demographics
Median age at diagnosis was 53 years, with most patients having FIGO stage III and serous histology.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI, 1.5 to 3.2
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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