Pancreas Transplantation and Age-Related Morbidity
Author Information
Author(s): Afaneh Cheguevara, Rich Barrie S., Aull Meredith J., Hartono Choli, Leeser David B., Kapur Sandip
Primary Institution: New York Presbyterian Hospital, Weill Cornell Medical College
Hypothesis
Does age increase morbidity in pancreas transplantation?
Conclusion
Older patients with type 1 diabetes are feasible candidates for pancreas transplantation, as surgical morbidity, incidence of infections, and acute rejection rates are low.
Supporting Evidence
- Older patients had a lower one-year acute rejection rate compared to younger patients.
- Surgical morbidity was not increased in older patients.
- The incidence of non-surgical infections was similar between age groups.
- Patient and graft survival rates were comparable between older and younger recipients.
Takeaway
This study shows that older people can safely get pancreas transplants without more problems than younger people.
Methodology
A retrospective review of 136 pancreas transplants performed from 1996 to 2010, comparing outcomes between patients younger and older than 50 years.
Potential Biases
There may be a bias in the follow-up schedule of older patients.
Limitations
This is a retrospective analysis from a single institution with a small sample size.
Participant Demographics
The study included 136 pancreas transplant patients, with 17 patients aged 50 years or older.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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