Optimizing Production of Serially Diluted Compounds
Author Information
Author(s): Cole O. Harris, Stephanie L. Schweiker
Primary Institution: GlaxoWellcome Research and Development
Hypothesis
Can a robotic system efficiently produce and distribute serial dilutions of compounds to multiple assay plates?
Conclusion
The automated system allows for the efficient production and distribution of serially diluted compounds to multiple assay plates, significantly improving throughput.
Supporting Evidence
- The system can produce over 200 serial dilution assay plates in a workday.
- The production rate of the system is 32 plates per hour.
- Goodness of fit data demonstrated the accuracy of the approach.
Takeaway
This study shows how robots can quickly make and share tiny amounts of chemicals for testing, helping scientists work faster.
Methodology
The study utilized a Tecan Genesis RSP 150 and Zymark track system to automate the production and distribution of serial dilutions.
Limitations
The accuracy of serial dilutions was compromised by carry-over issues specific to compound classes.
Digital Object Identifier (DOI)
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