Phosphorylation-Dependent 14-3-3 Binding to LRRK2 Is Impaired by Common Mutations of Familial Parkinson's Disease
2011
Impact of Mutations on LRRK2 Binding in Parkinson's Disease
publication
Author Information
Author(s): Li Xianting Wang, Qing Jun Pan, Nina Lee, Sangkyu Zhao, Yingming Chait, Brian T. Yue, Zhenyu
Hypothesis
Common mutations in familial Parkinson's disease impair phosphorylation-dependent binding of 14-3-3 to LRRK2.
Conclusion
The study found that certain mutations associated with familial Parkinson's disease negatively affect the binding of 14-3-3 proteins to LRRK2.
Takeaway
Some changes in genes related to Parkinson's disease make it harder for important proteins to stick together, which might affect how the disease works.
Digital Object Identifier (DOI)
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