The μ opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway
2006
Morphine's Effect on TRPV1 Responses
Sample size: 8
publication
Evidence: moderate
Author Information
Author(s): Irina Vetter, Bruce D. Wyse, Gregory R. Monteith, Sarah J. Roberts-Thomson, Peter J. Cabot
Primary Institution: The School of Pharmacy, The University of Queensland, Brisbane, Australia
Hypothesis
Can the μ opioid receptor agonist morphine modulate forskolin-potentiated capsaicin responses through a cAMP-dependent PKA pathway?
Conclusion
Morphine inhibits PKA-potentiated TRPV1 responses, suggesting it may help manage inflammatory pain.
Supporting Evidence
- Morphine significantly inhibited forskolin-induced cAMP production.
- TRPV1 and MOP were co-expressed in cultured Dorsal Root Ganglion neurons.
- Pre-treatment with morphine altered capsaicin responses in FSK-stimulated cells.
Takeaway
Morphine can help reduce pain by blocking certain signals in the body that make pain worse, especially when inflammation is present.
Methodology
The study used HEK293 cells stably expressing TRPV1 and MOP to monitor calcium responses to capsaicin.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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