Influence of Health System Affiliation and Pain Manifestation on Advanced Oral Cavity Squamous Cell Carcinoma Risk: A Retrospective Cohort Study in a Latin American Population
2024

Impact of Health System and Pain on Oral Cancer Risk

Sample size: 233 publication 10 minutes Evidence: moderate

Author Information

Author(s): Díaz-Laclaustra Alejandro I., Álvarez-Martínez Efraín, Ardila Carlos M.

Primary Institution: Universidad de Antioquia, Medellín, Colombia

Hypothesis

Disparities in health system affiliation and early pain presentation impact both the stage of diagnosis and the outcomes of OCSCC in these patients.

Conclusion

Men, referrals to pain clinics, and those without health insurance are at a higher risk of advanced oral cavity squamous cell carcinoma.

Supporting Evidence

  • 84.1% of patients had advanced OCSCC.
  • Men had a threefold increased risk of advanced OCSCC.
  • Patients referred to pain clinics had a 19.5 times higher risk.
  • Those in subsidized health systems had 2.6 times higher risk.
  • Patients without health insurance had 2.7 times higher risk.

Takeaway

This study found that men and people who go to pain clinics are more likely to have serious oral cancer. Also, not having health insurance makes it worse.

Methodology

Retrospective cohort study analyzing medical records of 233 patients with OCSCC treated at a public hospital.

Potential Biases

Potential biases due to retrospective data collection and lack of certain demographic information.

Limitations

The study is retrospective and may have biases related to variable control; small sample size for early-stage comparators.

Participant Demographics

Mean age 63 years, 53.6% male, 64% from urban areas, predominantly low socioeconomic status.

Statistical Information

P-Value

p<0.001

Confidence Interval

95% CI: 1.3–6.8

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.3390/dj12120383

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