Genetic Imprinting Analysis for Alcoholism Genes
Author Information
Author(s): Sanjay Shete, Robert Yu
Primary Institution: University of Texas M. D. Anderson Cancer Center
Hypothesis
Can genomic imprinting increase the power to detect genes linked to alcoholism?
Conclusion
Allowing for imprinting in linkage analyses can enhance the detection of genes associated with alcoholism.
Supporting Evidence
- Significant evidence of imprinting was found at two loci, D7S1790 and D1S1631.
- The study suggests that traditional linkage analyses may miss important genetic factors due to not accounting for imprinting.
- The variance-components approach allows for a more accurate analysis of genetic contributions to alcoholism.
Takeaway
This study looked at how genes from parents might affect alcoholism. It found that considering which parent a gene comes from can help find genes linked to alcoholism better.
Methodology
Used a variance-components approach to analyze quantitative traits related to alcoholism.
Limitations
The asymptotic distribution used may not be very accurate, and simulation-based p-values are recommended for confirmation.
Participant Demographics
143 families consisting of a total of 1,614 individuals.
Statistical Information
P-Value
0.00003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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