Genetic Factors in Nicotine Dependence and Smoking Cessation
Author Information
Author(s): Uhl George R, Liu Qing-Rong, Drgon Tomas, Johnson Catherine, Walther Donna, Rose Jed E
Primary Institution: Molecular Neurobiology Branch, NIH-IRP, NIDA
Hypothesis
Nicotine dependent participants in smoking cessation studies will display allele frequencies different from those identified in ethnically-matched control research volunteers.
Conclusion
The study identifies genetic variants associated with successful smoking cessation, suggesting that certain genes may influence an individual's ability to quit smoking.
Supporting Evidence
- Genetic vulnerabilities to nicotine dependence overlap with those for other addictive substances.
- Successful abstinence from nicotine has heritable components.
- Specific SNPs were identified that cluster in genomic regions related to smoking cessation.
Takeaway
Some people have genes that make it easier or harder for them to stop smoking, and this study found some of those genes.
Methodology
The study used genome-wide association studies comparing SNP allele frequencies in nicotine dependent individuals and control subjects.
Potential Biases
Potential bias due to overlapping control groups and modest sample sizes.
Limitations
The sample sizes were modest, which may limit the power to detect gene variants related to nicotine dependence and successful quitting.
Participant Demographics
Participants were of self-reported European ancestry, averaged age 44, and 45% female.
Statistical Information
P-Value
p < 0.005 for nicotine dependent vs control comparisons; p < 0.01 for successful vs unsuccessful quitters.
Statistical Significance
p < 0.005
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website