Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes
2008
Curcumin and Resveratrol Reduce Inflammation in Fat Cells
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Amanda M Gonzales, Robert A Orlando
Primary Institution: University of New Mexico, School of Medicine
Hypothesis
Can curcumin and resveratrol inhibit NF-κB activation in adipocytes and reduce cytokine expression?
Conclusion
Curcumin and resveratrol significantly reduce cytokine expression in adipocytes by inhibiting NF-κB signaling.
Supporting Evidence
- Curcumin and resveratrol inhibited NF-κB activation in adipocytes.
- Treatment with these compounds reduced the expression of pro-inflammatory cytokines.
- IC50 values for curcumin and resveratrol were found to be low, indicating high potency.
Takeaway
Curcumin and resveratrol are natural compounds that help reduce inflammation in fat cells, which can be good for health.
Methodology
The study measured cytokine gene expression in adipocytes using qRT-PCR and ELISA after treatment with curcumin and resveratrol.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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