Epstein-Barr Virus and Gastric Cancer in Iran
Author Information
Author(s): Abdirad Afshin, Ghaderi-Sohi Siavash, Shuyama Karem, Koriyama Chihaya, Nadimi-Barforoosh Hosain, Emami Sara, Mosavi-Jarrahi Alireza, Nahvijou Azin, Akiba Suminori
Primary Institution: The Cancer Research Center, the Cancer Institute, Tehran University of Medical Sciences
Hypothesis
What is the prevalence of Epstein-Barr virus in gastric carcinoma cases in Iran?
Conclusion
The study found a very low prevalence of Epstein-Barr virus-associated gastric carcinoma in Iran.
Supporting Evidence
- Only 3% of the gastric carcinoma cases were found to be EBV positive.
- EBV-GC cases had no relation with age, location, and invasion.
- The majority of EBV-GC cases were of diffuse type, which is consistent with findings in Latin America.
Takeaway
This study looked at stomach cancer cases in Iran and found that only a few had a virus linked to cancer, which is surprising.
Methodology
The study examined 273 gastric carcinoma cases for the presence of Epstein-Barr virus using in situ hybridization and PCR.
Potential Biases
The study's findings may not be generalizable due to the specific population and limited sample size.
Limitations
The low number of EBV-positive cases limited the statistical analysis.
Participant Demographics
The sample included 196 males (72%) and 77 females (28%), with a mean age of 57.3 years.
Statistical Information
P-Value
0.009
Confidence Interval
95% CI = 1–5%
Statistical Significance
p=0.009
Digital Object Identifier (DOI)
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