Alzheimer's Disease and Type 2 Diabetes: The Cholinesterase Connection
Author Information
Author(s): Allam Appa Rao, Sridhar Gumpeny Ramachandra, Thota Hanuman, Suresh Babu Changalasetty, Siva Prasad Akula, Divakar Ch
Primary Institution: Andhra University
Hypothesis
We sought to identify protein(s) common to both conditions that could suggest a possible unifying pathogenic role.
Conclusion
Butyrylcholinesterase and acetylcholinesterase related proteins may play an etiological role in both Alzheimer's disease and diabetes by influencing insulin resistance and lipid metabolism.
Supporting Evidence
- Alzheimer's disease and type 2 diabetes mellitus occur with increasing frequency as age advances.
- Epidemiological studies have shown an association of diabetes mellitus and Alzheimer's disease.
- Identification of such sequences would provide leads for further understanding etiological, therapeutic or prognostic aspects.
Takeaway
This study looks at proteins that are common in both Alzheimer's disease and diabetes, suggesting they might be connected in how they affect our bodies.
Methodology
Used BLAST Tool for protein comparison and identified sequences common to both Alzheimer's disease and diabetes.
Limitations
The study does not establish a direct cause-effect relationship among the variables discussed.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website