Prognostic Significance of Apoptosis-Associated Proteins in Nephroblastoma
Author Information
Author(s): Ghanem M A, Kwast T H Van der, Hollander J C Den, Sudaryo M K, Heuvel M M Van den, Noordzij M A, Nijman R J M, Soliman E H, Steenbrugge G J van
Primary Institution: Dept. of Paediatric Urology and Pathology, Josephine Nefkens Institute
Hypothesis
The study evaluates the prognostic value of apoptosis-associated proteins BCL-2, BAX, and BCL-X in Wilms' tumours.
Conclusion
The study found that alterations in the Bcl-2/Bax balance can influence the clinical outcome of Wilms' tumour patients.
Supporting Evidence
- Bcl-2, Bax, and Bcl-X S/L were expressed in the blastemal and epithelial components of Wilms' tumour.
- 53% of tumours showed immunoreactive blastema cells for Bcl-2.
- 41% of tumours showed immunoreactive blastema cells for Bax.
- 38% of tumours showed immunoreactive blastema cells for Bcl-X S/L.
- Increased Bcl-2 expression was observed in the blastemal component of higher pathological stages.
- Bax expression declined in the blastemal component with increasing pathological stages.
- Blastemal Bcl-X S/L expression also decreased with stage.
- Blastemal Bcl-2 expression was an independent prognostic marker for clinical progression.
Takeaway
This study looked at how certain proteins in kidney tumors can help predict how well a patient will do.
Methodology
The study used an immunohistochemical approach to evaluate protein expression in Wilms' tumours.
Participant Demographics
Patients with Wilms' tumours who were chemotherapeutically pre-treated.
Digital Object Identifier (DOI)
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