Cardiorespiratory Events After DTP-IPV-Hib Immunization in Preterm Infants
Author Information
Author(s): Jackie Lee, Joan L. Robinson, Donald W. Spady
Primary Institution: University of Alberta
Hypothesis
Does the type of pertussis vaccine affect the frequency of apnea, bradycardia, and desaturations in preterm infants after immunization?
Conclusion
There is an increase in adverse cardiorespiratory events following the first dose of DTP-IPV-Hib in preterm infants, with lower current weight identified as a risk factor.
Supporting Evidence
- 45.1% of immunized infants had increased cardiorespiratory events post-immunization.
- Lower weight at immunization was a risk factor for increased adverse events.
- The incidence of adverse events was similar for both whole cell and acellular pertussis vaccines.
Takeaway
When preterm babies get their first vaccine, some might have trouble breathing or heart issues afterward, especially if they are lighter.
Methodology
A retrospective cohort study comparing adverse cardiorespiratory events in preterm infants receiving DTP-IPV-Hib immunization to matched controls.
Potential Biases
Potential bias in monitoring practices and control selection.
Limitations
Infants not on monitors were excluded, potentially overestimating the frequency of adverse events.
Participant Demographics
Infants with gestational age of ≤ 32 weeks, 58% male.
Statistical Information
P-Value
0.89
Confidence Interval
95% CI 1.29, 4.51
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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