Impact of Trivalent Arsenicals on Selenoprotein Synthesis
Author Information
Author(s): Ganyc Denis, Talbot Sarah, Konate Fanta, Jackson Sarah, Schanen Brian, Cullen William, Self William T.
Primary Institution: University of Central Florida
Hypothesis
Changes in selenoprotein synthesis may be an underlying mechanism behind arsenic-induced carcinogenesis.
Conclusion
Arsenite and MMAIII affect selenoprotein synthesis, which may contribute to higher cancer rates in populations exposed to arsenic.
Supporting Evidence
- Arsenite treatment blocked new synthesis of selenoproteins when selenium was present as selenite.
- MMAIII increased levels of TrxR1 but reduced cGpx synthesis.
- DMAIII stimulated selenoprotein synthesis by an unknown mechanism.
Takeaway
This study shows that certain arsenic compounds can block the production of important proteins that help protect cells from damage, which might lead to cancer.
Methodology
The study analyzed selenoprotein synthesis in human keratinocyte cells after exposure to inorganic and methylated arsenicals.
Limitations
The study primarily used cell culture models, which may not fully represent in vivo conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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