Alcohol and Breast Cancer Risk by Hormone Receptor Status
Author Information
Author(s): Enger S M, Ross R K, Paganini-Hill A, Longnecker M P, Bernstein L
Primary Institution: Kaiser Permanente Medical Care Program
Hypothesis
Does alcohol consumption affect the risk of breast cancer based on oestrogen and progesterone receptor status?
Conclusion
Alcohol may increase the risk of ER-positive/PR-positive breast cancer in postmenopausal women.
Supporting Evidence
- Alcohol use was not associated with premenopausal breast cancer risk.
- Postmenopausal women consuming ≥ 27 g of alcohol/d had a higher odds ratio for ER-positive/PR-positive breast cancer.
Takeaway
Drinking alcohol might make older women more likely to get a certain type of breast cancer.
Methodology
Data from two case-control studies in Los Angeles County were analyzed, focusing on premenopausal and postmenopausal women.
Potential Biases
Potential bias in matching controls and self-reported alcohol consumption.
Limitations
The study may not account for all potential confounding factors related to breast cancer risk.
Participant Demographics
733 premenopausal women aged ≤ 40 and 1169 postmenopausal women aged 55–64.
Statistical Information
P-Value
0.05
Confidence Interval
1.14–2.71
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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