The Histopathology of Septic Acute Kidney Injury
Author Information
Author(s): Christoph Langenberg, Sean M Bagshaw, Clive N May, Rinaldo Bellomo
Primary Institution: Austin Hospital, University of Melbourne, University of Alberta Hospital
Hypothesis
What are the histopathological changes associated with septic acute kidney injury?
Conclusion
There are no consistent renal histopathological changes in human or experimental septic AKI, with ATN being relatively uncommon.
Supporting Evidence
- Only 22% of patients had features suggestive of acute tubular necrosis (ATN).
- In human studies, ATN was a relatively uncommon finding.
- The majority of studies reported normal histology or only mild, nonspecific changes.
Takeaway
Doctors looked at kidney samples from sick patients to see if they had damage from sepsis, but they found that most kidneys looked normal or only a little damaged.
Methodology
A systematic review of studies describing kidney histopathology in septic AKI was performed using multiple databases.
Potential Biases
Potential biases due to late sampling and confounding factors in study designs.
Limitations
The study sample was small and varied in design, with many studies being observational and lacking controls.
Participant Demographics
Included both human and animal studies, with a total of 184 patients and various animal models.
Statistical Information
P-Value
0.43
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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