Insoluble Glycogen Reduces Lethality in Endotoxin Shock in Rats
Author Information
Author(s): S. Sipka, G. Bot, P. Gergely, L. Berto, J. Csongor, P. Sapy, M. Szappanos, J. Nemes, E. Duda, G. Szegedi
Primary Institution: University Medical School of Debrecen
Hypothesis
Can insoluble glycogen decrease the lethality of endotoxin shock in rats?
Conclusion
Insoluble glycogen completely prevented lethality in rats subjected to endotoxin shock.
Supporting Evidence
- All animals treated with insoluble glycogen survived.
- The LD50 dose of endotoxin was found to be 2 mg.
- Insoluble glycogen binds various toxic substances in vitro.
- Chemiluminescence increased significantly when ISG was combined with phosphorylase-a.
Takeaway
Insoluble glycogen helps rats survive when they are sick from a bad bacteria, like a superhero for their bodies.
Methodology
Wistar male rats were sensitized to endotoxin and treated with insoluble glycogen before exposure to endotoxin; survival was evaluated after 12 hours.
Limitations
The beneficial effect of insoluble glycogen was only observed when administered just before endotoxin exposure.
Participant Demographics
Wistar male rats, 200 g
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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