Impact of Maternal Separation on Dental Enamel Development
Author Information
Author(s): de Sousa Júlia Ingryd Targino, Gonçalves Juliana de Lima, de Queiroz Alexandra Mussolino, de Carvalho Fabrício Kitazono, de Paula-Silva Francisco Wanderley Garcia
Primary Institution: Department of Pediatric Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Hypothesis
This study aims to investigate whether postnatal maternal separation stress impacts enamel development in a murine experimental model.
Conclusion
The study will explore how stress may potentially be linked to the etiology of molar incisor hypomineralization.
Supporting Evidence
- Dental enamel is influenced by genetic and environmental factors.
- Maternal stress and adverse events in early life can impact enamel development.
- Stress can lead to developmental defects such as molar incisor hypomineralization.
Takeaway
This study is looking at how separating baby rats from their mothers might affect their teeth as they grow up.
Methodology
The study will use a maternal separation model in rats to assess the impact on enamel development through various analyses including microhardness testing and histological evaluations.
Limitations
No datasets were generated or analyzed during the current study; all relevant data will be made available upon study completion.
Participant Demographics
Four pregnant Wistar rats will be used for the study.
Digital Object Identifier (DOI)
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