Effect of Goshajinkigan on Nerve Damage from Chemotherapy
Author Information
Author(s): Toru Kono, Noriaki Mamiya, Naoyuki Chisato, Yosiaki Ebisawa, Hirotaka Yamazaki, Jiro Watari, Yasuhiro Yamamoto, Shigetaka Suzuki, Toshiyuki Asama, Kazunori Kamiya
Primary Institution: Asahikawa Medical University
Hypothesis
Does Goshajinkigan reduce peripheral neurotoxicity in patients receiving oxaliplatin for colorectal cancer?
Conclusion
Goshajinkigan significantly reduces the incidence of peripheral neurotoxicity in patients undergoing oxaliplatin therapy.
Supporting Evidence
- Patients receiving Goshajinkigan had a lower incidence of peripheral neuropathy compared to those who did not.
- No cases of Grade 3 peripheral neuropathy were reported in the Goshajinkigan group.
- The total dose of oxaliplatin at which 50% of patients developed neuropathy was higher in the Goshajinkigan group.
Takeaway
This study found that a herbal medicine called Goshajinkigan helps protect patients from nerve damage caused by a cancer drug called oxaliplatin.
Methodology
Retrospective analysis comparing four groups of patients receiving different treatments alongside oxaliplatin.
Potential Biases
Differences in baseline characteristics among groups may introduce bias.
Limitations
The study was retrospective and had a small sample size.
Participant Demographics
90 patients with advanced or recurrent colorectal cancer, median age 63, mixed gender.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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