Arboviral Infections in Rural Kenyan Adults
Author Information
Author(s): Mease Luke E, Coldren Rodney L, Musila Lillian A, Prosser Trish, Ogolla Fredrick, Ofula Victor O, Schoepp Randal J, Rossi Cindy A, Adungo Nicholas
Primary Institution: Walter Reed Army Institute of Research
Hypothesis
What is the seroprevalence and distribution of arboviral infections among rural Kenyan adults?
Conclusion
A significant proportion of rural Kenyan adults have been infected by arboviruses, with varying seroprevalence across different districts.
Supporting Evidence
- 46.6% of participants had antibodies to at least one arbovirus.
- Seroprevalence varied significantly by district.
- Literacy was associated with increased seropositivity for some viruses.
Takeaway
Many adults in rural Kenya have been sick from viruses spread by bugs, and where you live can change how likely you are to get sick.
Methodology
A cross-sectional study design was used, involving a questionnaire and blood tests for antibodies against several arboviruses.
Potential Biases
Potential cross-reactivity between CHIKV and O'nyong-nyong virus may affect results.
Limitations
The study relied on non-validated ELISA assays and did not include individuals under 18 years of age.
Participant Demographics
The study included 1,141 adults, predominantly female (64.1%), from three districts in Kenya.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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