Macrophages in Human Breast Disease
Author Information
Author(s): P.M.A. Kelly, R.S. Davison, E. Bliss, J. O'D. McGee
Primary Institution: Nuffield Department of Pathology, University of Oxford
Hypothesis
Do macrophage counts differ between benign and malignant breast tissue?
Conclusion
Malignant breast tissue contains significantly higher numbers of macrophages compared to benign tissue.
Supporting Evidence
- Macrophage counts were significantly higher in malignant breast tissue compared to benign tissue.
- The study used a specific monoclonal antibody to identify macrophages.
- Follow-up records showed no local recurrence or distant metastasis in the carcinoma patients during the study period.
Takeaway
This study looked at breast tissue samples and found that cancerous tissues have more macrophages than non-cancerous ones.
Methodology
The study analyzed 34 breast biopsies using the monoclonal antibody EBM/11 to count macrophages.
Limitations
The follow-up period was relatively short, averaging just over two years.
Participant Demographics
17 benign cases with a mean age of 42.25 years and 17 malignant cases with a mean age of 56 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website