Carotid Blood Flow and Cardiac Output in Pigs with Sepsis
Author Information
Author(s): Correa T, Blaser A, Reintam J, Takala J, Djafarzadeh S, Vuda M, Dünser M, Jakob S Mathias
Primary Institution: University Hospital Bern - Inselspital and University of Bern, Switzerland
Hypothesis
Does carotid blood flow depend on cardiac output and mean arterial blood pressure in abdominal sepsis?
Conclusion
Increasing systemic blood flow can improve carotid blood flow, but blood pressure does not have the same effect.
Supporting Evidence
- In septic animals, carotid blood flow index and cardiac index were positively correlated.
- In controls, carotid blood flow index and mean arterial pressure were weakly and inversely correlated.
Takeaway
This study found that in pigs with sepsis, better blood flow to the brain is linked to better heart output, not blood pressure.
Methodology
Thirty-two anesthetized pigs were divided into groups to study the effects of resuscitation on carotid blood flow, cardiac output, and arterial blood pressure.
Participant Demographics
Anesthetized pigs weighing approximately 40.3 kg.
Statistical Information
P-Value
P < 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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