Estimating Cardiac Output in Heart Failure Patients
Author Information
Author(s): Karamanoglu Mustafa, Bennett Tom, Ståhlberg Marcus, Splett Vincent, Kjellström Barbro, Linde Cecilia, Braunschweig Frieder
Primary Institution: Medtronic Inc, Minneapolis, Minnesota, USA; Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Hypothesis
Can cardiac output be estimated from right ventricular pressure waveforms in patients with congestive heart failure?
Conclusion
The analysis of right ventricular pressure waveforms can provide an estimate of cardiac output and may help guide treatment in patients with congestive heart failure.
Supporting Evidence
- The algorithm derived cardiac output estimates correlated with Fick CO (R2 = 0.92).
- During sub-maximal exercise, total pulmonary arterial resistance decreased significantly.
- Cardiac output increased significantly during exercise compared to rest.
Takeaway
Doctors can use special sensors to measure heart output in patients with heart failure, which helps them treat the patients better.
Methodology
The study involved 12 patients with CHF, where cardiac output was measured using breath-by-breath Fick method and compared with estimates from an implantable hemodynamic monitor during exercise.
Potential Biases
Potential bias due to the small number of patients and retrospective data analysis.
Limitations
The study had a small sample size and the results may not reflect ambulatory conditions.
Participant Demographics
All participants were male patients with chronic heart failure, aged between 52 and 79 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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