New Therapy for Malignant Pleural Effusion
Author Information
Author(s): Hansen Pernille Schjødt, Graversen Martin, Detlefsen Sönke, Ainsworth Alan Patrick, Mortensen Michael Bau
Primary Institution: Odense University Hospital, Odense, Denmark
Hypothesis
Is Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) a safe and effective treatment for patients with malignant pleural effusion and pleural metastasis?
Conclusion
PITAC appears to be safe and feasible for treating patients with malignant pleural effusion and pleural metastasis.
Supporting Evidence
- Nine out of eleven intended PITAC procedures were completed.
- One patient showed complete response and another stable disease after treatment.
- 30-day mortality was zero among the patients treated.
Takeaway
Doctors are trying a new way to treat patients with fluid in their lungs caused by cancer, and it seems to be safe.
Methodology
This study analyzed patients treated with PITAC at Odense PIPAC Center from February 2018 to September 2021, focusing on feasibility, safety, and response assessment.
Potential Biases
Potential biases due to the retrospective nature and lack of control group.
Limitations
The study is retrospective and includes a small sample size with heterogeneous patient characteristics.
Participant Demographics
Patients included had various primary cancers, with a mix of genders and ages ranging from 53 to 67 years.
Digital Object Identifier (DOI)
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