Diosmectite for Treating Diarrhoea in Adults
Author Information
Author(s): Khediri Faouzi, Mrad Abdennebi Ilhem, Azzouz Moussadek, Doughi Hedi, Najjar Taoufik, Mathiex-Fortunet Hélène, Garnier Philippe, Cortot Antoine
Hypothesis
Diosmectite will reduce the time to recovery from acute watery diarrhoea in adults compared to placebo.
Conclusion
Diosmectite at 6 g three times a day was well tolerated and significantly reduced the time to recovery from acute watery diarrhoea in adults.
Supporting Evidence
- The median time to recovery was 53.8 hours for diosmectite compared to 69.0 hours for placebo.
- Diosmectite was well tolerated with a low incidence of adverse events.
- Statistical analysis showed a significant difference in recovery time favoring diosmectite.
Takeaway
Diosmectite helps adults with watery diarrhoea get better faster.
Methodology
346 adults were randomized to receive either diosmectite or placebo for four days, and the primary endpoint was time to recovery from diarrhoea.
Potential Biases
Potential bias due to the exclusion of patients with major protocol deviations.
Limitations
The study was limited to a specific population in Tunisia, which may affect generalizability.
Participant Demographics
Outpatient males and nonpregnant women aged 18 to 65 years.
Statistical Information
P-Value
0.029
Statistical Significance
p = 0.029
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website