Chondroitin and Glucosamine Sulfate Reduce Bone Resorption in Osteoarthritis
Author Information
Author(s): Kwan Tat, Pelletier Jean-Pierre, Vergés Josep, Lajeunesse Daniel, Montell Eulàlia, Fahmi Hassan, Lavigne Martin, Martel-Pelletier Johanne
Primary Institution: Osteoarthritis Research Unit, University of Montreal Hospital Centre
Hypothesis
Do chondroitin sulfate and glucosamine sulfate affect bone biomarkers and the pro-resorptive activity of osteoblasts in human osteoarthritis?
Conclusion
Chondroitin sulfate and glucosamine sulfate, alone or in combination, do not significantly affect osteoblast integrity but can reduce bone resorption activity.
Supporting Evidence
- Chondroitin sulfate and glucosamine sulfate did not significantly affect alkaline phosphatase or osteocalcin release.
- OPG expression was significantly increased with chondroitin sulfate and both drugs combined.
- RANKL expression was significantly reduced by chondroitin sulfate and both drugs combined.
- The combination of chondroitin sulfate and glucosamine sulfate significantly reduced resorption activity.
Takeaway
This study found that two common supplements, chondroitin and glucosamine, can help protect bones in people with arthritis by reducing bone breakdown.
Methodology
The study involved human osteoblasts from osteoarthritis patients, treated with chondroitin sulfate and glucosamine sulfate, and assessed for bone biomarkers and resorption activity.
Potential Biases
Potential conflicts of interest due to funding from a company that produces the supplements.
Limitations
The study was limited to a specific patient population and may not generalize to all osteoarthritis patients.
Participant Demographics
Patients undergoing total knee arthroplasty, mean age 74 years.
Statistical Information
P-Value
p<0.04 for CS and GS alone; p<0.01 for CS and GS combined
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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