Impact of HIF on Tumor Growth and Invasion
Author Information
Author(s): Spinicci Kévin, Powathil Gibin, Stéphanou Angélique
Primary Institution: Université Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, Grenoble, France
Hypothesis
How does the Hypoxia Inducible Factor (HIF) influence tumor metabolism and cell migration?
Conclusion
The study found that HIF affects collagen remodeling and tumor growth, but does not influence the Warburg effect.
Supporting Evidence
- HIF impacts collagen remodeling and tumor growth.
- Cell migration speed is influenced by collagen density.
- Lower oxygen levels combined with higher collagen reduce tumor proliferation.
- Collagen conditions affect the shape of the tumor.
- The Warburg effect was not observed under the studied conditions.
Takeaway
This study looks at how a protein called HIF affects how tumors grow and spread by changing the collagen around them.
Methodology
An agent-based model was developed to simulate tumor growth and the effects of HIF on metabolism and collagen processes.
Limitations
The model was limited to 2D simulations and did not account for the effects of extracellular pH on the matrix.
Digital Object Identifier (DOI)
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