Intratumoral Oestrone Sulphatase Activity in Breast Cancer
Author Information
Author(s): T.R.J. Evans, M.G. Rowlands, M. Law, R.C. Coombes
Primary Institution: St. George's Hospital Medical School
Hypothesis
Is intratumoral oestrone sulphatase activity a prognostic marker in human breast carcinoma?
Conclusion
Oestrone sulphatase activity is not a significant prognostic factor in breast carcinoma.
Supporting Evidence
- Oestrone sulphatase activity was detected in 93 of 104 human breast carcinoma samples (89%).
- There was no significant correlation between intratumoral oestrone sulphatase activity and oestrogen receptor status.
- Intratumoral enzyme levels were not associated with time to recurrence or overall survival time.
Takeaway
The study looked at an enzyme in breast cancer that makes estrogen, but it doesn't help predict how the cancer will behave.
Methodology
The study analyzed 104 breast carcinoma samples for oestrone sulphatase activity and its correlation with various prognostic factors.
Limitations
The study had a small sample size and insufficient power to detect modest associations.
Participant Demographics
Patients included both premenopausal and postmenopausal women with breast carcinoma.
Want to read the original?
Access the complete publication on the publisher's website