Topographic analysis of K-ras mutations in histologically normal lung tissues and tumours of lung cancer patients
2001
K-ras Mutations in Lung Cancer Patients
Sample size: 48
publication
Evidence: moderate
Author Information
Author(s): Keohavong P, Mady H H, Gao W M, Siegfried J M, Luketich J D, Melhem M F
Primary Institution: University of Pittsburgh Cancer Institute
Hypothesis
The timing of K-ras mutations in lung cancer development is poorly understood.
Conclusion
K-ras mutations are common in histologically normal lung cells and may indicate early events in lung cancer development.
Supporting Evidence
- K-ras mutations were found in 26.3% of lung adenocarcinomas.
- No K-ras mutations were detected in lung squamous cell carcinomas.
- Some mutations were found in both tumor and histologically normal tissues.
Takeaway
Scientists looked at lung cancer patients and found that some normal-looking lung cells had mutations that could lead to cancer.
Methodology
K-ras mutations were analyzed in cell samples from lung tissue sections using laser capture microscopy.
Participant Demographics
Lung cancer patients, including 38 with adenocarcinomas and 10 with squamous cell carcinomas.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website