Cardiorenal Effects of Celecoxib vs Ibuprofen in Arthritis Patients
Author Information
Author(s): Hegazy Ragia, Alashhab Mohamed, Amin Madiha
Primary Institution: Benha Faculty of Medicine, Benha University
Hypothesis
Celecoxib has reduced cardiorenal toxicity compared to ibuprofen in patients with arthritis.
Conclusion
Celecoxib is associated with a lower incidence of cardiorenal toxicity compared to ibuprofen.
Supporting Evidence
- Patients taking celecoxib had significantly lower rates of hypertension compared to those taking ibuprofen.
- Serum creatinine levels increased significantly in patients treated with ibuprofen compared to celecoxib.
- Creatinine clearance was significantly lower in patients treated with ibuprofen compared to those treated with celecoxib.
Takeaway
This study found that celecoxib is safer for the heart and kidneys than ibuprofen for people with arthritis.
Methodology
The study involved 792 arthritic patients who were treated with either celecoxib or ibuprofen for 6 months, with various health effects monitored.
Potential Biases
Potential bias due to the exclusion of patients with renal insufficiency.
Limitations
The study did not include patients with abnormal renal functions at baseline, which may limit the applicability of the results.
Participant Demographics
Mean age was about 55 years, with 69%-71% being female.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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