FGF21 and Its Role in Reducing Glioblastoma Risk
Author Information
Author(s): Chen Xuan, Han Lihui, Xu Wenzhe
Primary Institution: Qilu Hospital of Shandong University
Hypothesis
The effect of inflammation on glioblastoma development might be mediated through specific blood metabolites.
Conclusion
FGF21 was causally associated with a reduced risk of glioblastoma, and this relationship is partially mediated by 3-methoxytyrosine.
Supporting Evidence
- Three inflammatory factors showed significant associations with glioblastoma.
- FGF21 had a protective effect against glioblastoma.
- 3-methoxytyrosine was identified as a significant mediator in the relationship between FGF21 and glioblastoma.
Takeaway
This study found that a protein called FGF21 can help lower the risk of a serious brain cancer called glioblastoma, and it does this partly by affecting a substance in the blood called 3-methoxytyrosine.
Methodology
A bidirectional two-sample Mendelian randomization approach was used to investigate causal associations between inflammatory factors and glioblastoma, followed by mediation analysis.
Potential Biases
Potential unmeasured confounding factors may impact findings.
Limitations
The generalizability of findings is limited due to the majority of participants being of European descent, and the study used summary-level statistics rather than individual-level data.
Participant Demographics
Majority of participants were of European descent.
Statistical Information
P-Value
1.00×10-3
Confidence Interval
0.25, 0.71
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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