HPV in Breast Tumors Among Mexican Patients
Author Information
Author(s): David Cantu de León, Delia Pérez Montiel, Jana Nemcova, Iva Mykyskova, Elmer Turcios, Verónica Villavicencio, Lucely Cetina, Alberto Coronel, Ondrej Hes
Primary Institution: Instituto Nacional de Cancerología, México City, México
Hypothesis
What is the prevalence of HPV DNA in patients with breast lesions at the Instituto Nacional de Cancerologia de Mexico?
Conclusion
The presence of HPV in breast cancer cases is significant, suggesting a potential role of the virus in breast cancer pathogenesis.
Supporting Evidence
- 1.9% of the cancer group had HPV, while none in the benign group.
- 29.4% of breast cancer cases were positive for HPV DNA.
- HPV 16 was the most common type found in positive cases.
Takeaway
This study looked at breast cancer patients in Mexico and found that some had a virus called HPV, which might be linked to their cancer.
Methodology
The study analyzed 51 breast cancer cases and 43 non-malignant cases, using PCR to detect HPV DNA.
Potential Biases
There may be risks of bias due to the retrospective nature of the study and selection of cases.
Limitations
The study's findings may be limited by the small sample size and the potential discrepancies in PCR sensitivity.
Participant Demographics
All participants were Mexican women, with a mean age of 53.3 years.
Statistical Information
P-Value
0.008
Statistical Significance
p=0.008
Digital Object Identifier (DOI)
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