Serum pTau181 and Neurofilament Light Elevations Correlate with Opioid Use and Fecundity
Author Information
Author(s): Emily Hanson, Karl Berner, Jon Berner
Primary Institution: Woodinville Psychiatric Associates
Hypothesis
The study investigates the relationship between serum tau and neurofilament light levels with opioid use and fecundity in a psychiatric clinic.
Conclusion
The study found that tau levels are associated with opioid use and increased fecundity, while amyloid levels are associated with decreased fecundity.
Supporting Evidence
- Tau associates with opioid use and increased fecundity.
- Adverse amyloid ratio associates with decreased fecundity.
- Previous studies documented elevated pTau181 and TNFa in patients with pain.
Takeaway
This study looked at how certain brain markers relate to pain medication use and having children, finding that one marker is linked to both.
Methodology
Chart review of an initial cohort screening for dementia risk.
Participant Demographics
Participants were from a psychiatric clinic.
Statistical Information
P-Value
p=0.01 for tau and opioid use; p=0.079 for tau and fecundity; p=0.067 for amyloid and fecundity.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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