Voluntary Exercise Reduces Intestinal Tumors in Mice
Author Information
Author(s): Ju Jihyeung, Nolan Bonnie, Cheh Michelle, Bose Mousumi, Lin Yong, Wagner George C, Yang Chung S
Primary Institution: Rutgers, The State University of New Jersey
Hypothesis
Does voluntary exercise inhibit intestinal tumor formation in ApcMin/+ mice and AOM/DSS-treated mice?
Conclusion
Voluntary exercise inhibited intestinal tumorigenesis in ApcMin/+ mice and AOM/DSS-treated mice, linked to decreased IGF-1/IGFBP-3 ratio and altered signaling pathways.
Supporting Evidence
- Voluntary exercise decreased the number of small intestinal tumors in ApcMin/+ mice by 31%.
- Exercise led to a 51% decrease in omental fat pad weight/body weight in ApcMin/+ mice.
- Serum IGFBP-3 levels increased by 19% with exercise in ApcMin/+ mice.
Takeaway
Letting mice run on wheels helped them grow fewer tumors in their intestines, showing that exercise can be good for preventing cancer.
Methodology
Mice were divided into groups with and without access to running wheels, and tumor counts were measured after specific periods of exercise.
Potential Biases
Potential bias due to group housing affecting individual exercise levels.
Limitations
The study did not account for individual differences in exercise access among group-housed mice.
Participant Demographics
Female ApcMin/+ mice and male CF-1 mice were used in the study.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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