Prognostic Nutritional Index and Lung Cancer Survival
Author Information
Author(s): Wang Lei, Long Xingxia, Zhu Ying, Luo Ailin, Yang Mei
Primary Institution: West China Hospital, Sichuan University, Chengdu, China
Hypothesis
This meta-analysis aimed to identify the association of prognostic nutritional index (PNI) with long-term survival in lung cancer patients who received immune checkpoint inhibitors.
Conclusion
PNI is significantly associated with long-term survival in immune checkpoint inhibitors treated lung cancer and patients with lower PNI are more likely to experience poorer prognosis.
Supporting Evidence
- Lower PNI was related to worse progression-free survival (PFS) and overall survival (OS).
- Subgroup analysis showed consistent findings across different types of lung cancer.
- PNI can effectively assess the prognosis of various cancer patients.
Takeaway
If lung cancer patients have a low nutritional score, they might not live as long when treated with certain cancer drugs.
Methodology
The study conducted a systematic review and meta-analysis of 22 studies, evaluating the association between PNI and survival outcomes in lung cancer patients treated with immune checkpoint inhibitors.
Potential Biases
Potential bias due to the retrospective nature of the studies and the predominance of studies from specific regions.
Limitations
The sample size is relatively small, all included studies are retrospective, and most studies are from Asian countries.
Participant Demographics
Most studies focused on non-small cell lung cancer patients from China and Japan.
Statistical Information
P-Value
<.001
Confidence Interval
0.43–0.61
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website