Left Ventricular Strain in Cancer Patients on Immunotherapy
Author Information
Author(s): Ece Celebi Coskun, Alper Coskun, Ahmet Bilgehan Sahin, Levent Fatih, Eyup Coban, Fatih Koca, Seda Sali, Omer Furkan Demir, Adem Deligonul, Erhan Tenekecioglu, Erdem Cubukcu, Turkkan Evrensel, Fahriye Vatansever Agca
Primary Institution: University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital
Hypothesis
Is left ventricular global longitudinal strain (LV GLS) a predictor for early detection of cardiac dysfunction in patients receiving immune checkpoint inhibitors (ICI)?
Conclusion
The study found that a reduction in LV GLS did not significantly predict ICI-related myocarditis or cardiac dysfunction.
Supporting Evidence
- Patients with reduced LV GLS had a significant decrease of 15%, while those with preserved LV GLS had a decrease of 7.6%.
- Two patients experienced significant decreases in LVEF and LV GLS, with one succumbing to myocarditis.
- 64% of the patients were male, and the median age was 64 years.
Takeaway
Doctors looked at heart strain in cancer patients getting special treatments to see if it could help catch heart problems early, but it didn't work as well as hoped.
Methodology
This was a retrospective cohort study assessing LV GLS and LVEF in 44 cancer patients before and after ICI treatment.
Limitations
The study had a small sample size and short follow-up period.
Participant Demographics
The median age of participants was 64 years, with 64% male and 36% female.
Statistical Information
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
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